Abstract #0321

Myelin Lipid 1H Density Measurements by IR-UTE are Consistent Before and After D2O Exchange

Alan C Seifert^1,2, Michael J Wilhelm³, Suzanne L Wehrli⁴, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Chemistry, Temple University, Philadelphia, PA, United States, ⁴SAIF Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States

In this work, the efficacy of long-T₂ tissue water suppression by adiabatic inversion-recovery preparation is examined by IR-UTE imaging of an ovine spinal cord specimen in native hydration and deuterium oxide (D₂O)-exchanged states. Myelin density in three white matter regions of interest (ROIs) was found to be 18.1% to 23.5% in the non-exchanged cord, and 19.9% to 22.5% in the D₂O-exchanged cord, with the highest density in the dorsal columns. The agreement of myelin density measurements between non-exchanged and D₂O-exchanged cords supports the efficacy of tissue water suppression in white matter by adiabatic inversion-recovery with an appropriately-chosen TI.

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