Abstract #0318

Evaluation of a wave-MPRAGE sequence for brain morphometery

Ross W. Mair^1,2, Jared A. Nielsen^1,3,4, and Randy L. Buckner^1,2,3,4

¹Center for Brain Science, Harvard University, Cambridge, MA, United States, ²AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Psychology, Harvard University, Cambridge, MA, United States, ⁴Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States

A new readout method for 3D scans, wave-CAIPI, with low g-factor characteristics that enable high degrees of acceleration, can reduce the scan time for a 1.0 mm MPRAGE to under 90 seconds. We have validated the morphometrics from this rapid wave-MPRAGE with those from conventional MPRAGE scans. The wave-MPRAGE sequence produces a lower-SNR image of the brain, but surfaces created from the wave images match those from the conventional scans well. In morphometric data, a bias is seen toward the conventional MPRAGE scans in average cortical thickness and estimated total intra-cranial volume, however values for total brain volume are similar.

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