Abstract #0315

Using 3D high-resolution MR Fingerprinting (MRF) to assist detection and characterization of epileptic lesions

Dan Ma¹, Irene Wang², Imad Najm², Anagha Deshmane³, Debra McGivney¹, Ken Sakaie⁴, Mark Lowe⁴, Vikas Gulani¹, Mark Griswold¹, and Stephen Jones^4,5

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Epilepsy Center, Cleveland Clinic, Cleveland, OH, United States, ³Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Neuroradiology, Cleveland Clinic, Cleveland, OH, United States

The goal of this study is to develop 3D high resolution MRF scans and partial volume analysis methods to assist detection and characterization of epileptogenic foci in patients with drug refractory epilepsy undergoing presurgical evaluation. In addition to providing quantitative T1/T2 values for tissue characterization, we hypothesize that quantitative maps also provide better sensitivity in detecting subtle epileptic lesions. To this end, high resolution T1 and T2 maps, as well as gray matter, white matter fractions maps and tissue cluster maps, were used to detect and characterize epileptic lesions that were difficult to identify from the weighted images and from conventional voxel-based post-processing analysis based on T1-weighted images.

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