Abstract #0307

Cerebral Blood Volume Mapping using Fourier-Transform based Velocity-Selective Saturation Pulse Trains

Qin Qin^1,2, Yaoming Qu³, Wenbo Li^1,2, Dapeng Liu^1,2, Taehoon Shin^4,5, Doris Lin¹, Peter van Zijl^1,2, and Zhibo Wen³

¹Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ⁴Ewha Womans University, Seoul, Republic of Korea, ⁵Case Western Reserve University, Cleveland, OH, United States

A new non-contrast cerebral blood volume (CBV) quantification technique is proposed using Fourier-transform based velocity-selective saturation (FT-VSS) pulse trains. Its utility is assessed for healthy subjects at 3T and compared to a method using conventional flow-dephasing VS pulse trains. FT-VSS showed greater immunity to gradient imperfections and up to 40% higher SNR. The better performance of FT-VSS pulse trains in CBV measurements can be explained by the effective background suppression related to its velocity-selective profile: static tissue signal in the saturation band and flowing spins in the passband, which is opposite from the velocity response of the conventional method.

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