Abstract #0303

Non-contrast assessment of blood-brain-barrier permeability with water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI

Zixuan Lin¹, Yang Li¹, Pan Su¹, Deng Mao¹, Zhiliang Wei¹, Jay Pillai¹, Abhay Moghekar², Matthias van Osch³, Yulin Ge⁴, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Radiology, New York University Langone Medical Center, New York, NY, United States

A new method for non-contrast assessment of blood-brain-barrier (BBB) permeability to water has been proposed: water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI, which allows selective imaging of venous ASL signal. Studies were performed to show proof-of-principle and Look-Locker readout were applied to expedite data acquisition. The results were consistent with previous literature. Mild hypercapnia was also shown to enhance the sensitivity of the technique significantly.

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