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Abstract #0289

The effects of cardiac allograft vasculopathy on intimal coronary artery wall thickness, myocardial fibrosis, and myocardial extracellular volume

Ruud B van Heeswijk1,2, Jessica AM Bastiaansen1, Juan F Iglesias3, Sophie Degrauwe3, Samuel Rotman4, Jérôme Yerly1,2, Giulia Ginami1,5, Matthias Stuber1,2, and Roger Hullin3

1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2Center for BioMedical Imaging (CIBM), Lausanne, Switzerland, 3Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Pathology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 5School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Cardiac allograft vasculopathy (CAV) occurs with a high prevalence after heart transplantation (HTx) and is a major cause of mid-term to late heart transplant failure. In this study we investigated whether the presence of CAV as diagnosed by x-ray coronary angiography or intima thickness as assessed by optical coherence tomography (OCT) is linked with the myocardial T1 relaxation time, extracellular volume, or interstitial fibrosis as assessed by endomyocardial biopsies (EMB).

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