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Abstract #0282

Magnetic susceptibility of hemorrhagic myocardial infarction: correlation with tissue iron and comparison with relaxation time MRI

Brianna F. Moon1, Srikant Kamesh Iyer PhD2, Michael P. Solomon1, Anya T. Hall1, Rishabh Kumar3, Elizabeth M. Higbee-Dempsey4, Andrew Tsourkas PhD1, Akito Imai MD5, Keitaro Okamoto MD5, Yoshiaki Saito MD5, Jerry Zsido II5, Joseph H. Gorman III MD5, Robert C. Gorman MD5, Giovanni Ferrari PhD6, and Walter R.T. Witschey PhD2

1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Biophysics, University of Pennsylvania, Philadelphia, PA, United States, 4Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States, 5Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 6Surgery, Columbia University, New York City, NY, United States

Hemorrhagic myocardial infarction (MI) is a frequent complication of primary percutaneous coronary intervention and independently associated with impaired LV remodeling, function, and arrhythmias. We demonstrate that cardiac quantitative susceptibility mapping (QSM) shows increased susceptibility in infarcts compared to remote myocardium and correlates with iron content and infarct pathophysiology. QSM is a more specific marker of hemorrhagic MI than relaxation time MRI, susceptibility-weighted imaging, and late gadolinium enhanced (LGE) MRI.

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