Abstract #0280

The Rate of Hyperpolarized [1-13C] Pyruvate to [1-13C] Lactate Conversion Distinguishes High-Grade Prostate Cancer from Low-Grade Prostate Cancer and Normal Peripheral Zone Tissue in Patients

Natalie Korn^1,2, Peder EZ Larson^1,2, Hsin-Yu Chen^1,2, Jeremy Gordon¹, Robert A Bok¹, Mark VanCriekinge¹, James Slater¹, Rahul Aggarwal³, Matthew Cooperberg³, Romelyn Delos Santos¹, Justin Delos Santos¹, Jeffry Simko⁴, Susan M Noworolski^1,2, Daniel B Vigneron^1,2, and John Kurhanewicz^1,2

¹Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States, ²The Graduate Group in Bioengineering, Universities of California at Berkeley and San Francisco, Berkeley and San Francisco, CA, United States, ³Urology, University of California at San Francisco, San Francisco, CA, United States, ⁴Pathology, University of California at San Francisco, San Francisco, CA, United States

The accurate discrimination of aggressive from indolent prostate cancer at diagnosis remains a pressing clinical need. High spatial and temporal resolution 3D dynamic hyperpolarized ¹³C MRSI has previously demonstrated the ability to correlate hyperpolarized (HP) [1-¹³C]pyruvate to [1-¹³C]lactate conversion, k_PL, with cancer grade in murine models. This initial analysis of patients studies enrolled in a phase II pre-prostatectomy clinical trial demonstrated for the first time that maxmium k_PL (k_PLmax) is significantly elevated in high-grade prostate cancer versus both normal (p=0.0003) and low-grade disease (p=0.034).

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