The goal of this feasibility study was to develop and apply new 3D dynamic hyperpolarized 13C combined parallel imaging + compressed sensing MRI methods for human brain studies. The new framework utilizing multichannel coils and low-rank matrix completion reconstruction provided greatly improved coverage as compared to prior 2D acquisitions. Whole-brain coverage was achieved, while maintaining the image quality in terms of spatial distribution, temporal dynamics and quantitative accuracy of the 13C biomarkers. Animal studies and simulations also showed that the pMRI+CS framework provided improved performance over CS alone, and was able better to recover low-SNR peaks.
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