Abstract #0132

Do Non-Gaussian diffusion MRI methods improve the detection or specification of cellular alterations following traumatic brain injury?

Elizabeth B Hutchinson^1,2, Sarah King¹, Alexandru Avram³, M Okan Irfanoglu¹, Michal Komlosh^2,4, Susan Schwerin^2,5, Eli Shindell⁵, Sharon Juliano⁵, and Carlo Pierpaoli¹

¹QMI/NIBIB, National Institutes of Health, Bethesda, MD, United States, ²Henry M. Jackson Foundation, Bethesda, MD, United States, ³NIBIB, National Institutes of Health, Bethesda, MD, United States, ⁴NICHD, National Institutes of Health, Bethesda, MD, United States, ⁵APG, Uniformed Services University, Bethesda, MD, United States

Following traumatic brain injury (TBI), numerous microscale cellular alterations appear and evolve with a range of consequences for adverse outcomes and recovery. Diffusion tensor MRI (DTI) has been identified as a potentially sensitive tool for characterizing these changes, but is notably limited in providing specific information about particular cellular alterations and more advanced non-Gaussian frameworks have been developed that may address these limitations. To assess the utility of non-Gaussian modeling for improved detection and specification of TBI-related cellular alterations, we compared DTI, DKI and MAP-MRI in mouse brains following mild TBI and their correspondence to histopathology in the same tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here