Abstract #0125

Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy

Helen Cheung¹, Paul J Karanicolas², Eugene Hsieh³, Natalie Coburn², Tishan Maraj¹, Jin J Kim¹, Howaida Elhakim³, Masoom A Haider¹, Calvin Law², and Laurent Milot¹

¹Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ²Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ³Department of Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

Preoperative MRI is routinely used for diagnosis, staging, and operative planning of colorectal liver metastases (CRCLM), but still relatively unexplored for preoperative prognosis. Tumour fibrosis in post-hepatectomy CRCLM specimens is associated with long-term survival and late gadolinium enhancement is associated with tumour fibrosis in other disease processes (eg. cholangiocarcinoma). We performed a retrospective cohort study (n=121) in patients who received a clinical gadolinium-enhanced MRI prior to hepatectomy for CRCLM. We determined that strong enhancement on delayed phase MRI was associated with tumour fibrosis post-hepatectomy and overall survival.

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