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Abstract #0123

Oxygen enhanced-MRI detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Ahmed Salem1,2, Ross Little3, Adam Featherstone3, Muhammad Babur4, Hitesh Mistry4, Susan Cheung3, Yvonne Watson3, Victoria Tessyman4, Marie-Claude Asselin3, Alan Jackson3, Kaye Williams4, Geoffrey Parker3,5, Corinne Faivre-Finn1,2, and James O'Connor1,6

1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 2Department of Clinical Oncology, The Christie Hospital NHS Trust, Manchester, United Kingdom, 3Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, 4Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom, 5Bioxydyn Ltd, Manchester, United Kingdom, 6Department of Radiology, The Christie Hospital NHS Trust, Manchester, United Kingdom

Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.

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Abstract