Abstract #0096

CEST MRI – a potential tool for breast cancer grade and proliferation rate differentiation

Olgica Zaric¹, Alex Farr², Esau Poblador Rodriguez¹, Vladimir Mlynarik¹, Claudia Kronnerwetter¹, Benjamin Schmitt³, Wolfgang Bogner¹, Christian Singer², and Siegfried Trattnig¹

¹High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria, ³Siemens Healthineers, Sydney, Australia

I this study, we investigated which CEST contrast changes are characteristic and dominant for breast malignancies. In 18 female patients, we performed DWI, CEST imaging, and T1-CE MRI. Significant differences in MTRasym between G1 and G3 was found (P= 0.007). Between G1 and G2 (P=0.066) as well as between G2 and G3 no difference were observed (P= 0.089). Correlation test demonstrated a strong positive correlation between mean MTRasym measured in region of its maximum and proliferation factor, Ki-67 (r=0.890, P˂0.001). This preliminary results show that CEST-MRI of the breast has a potential to provide information regarding the tumor histological features.

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