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Abstract #0091

The relevance of cortical lesions in cortical thinning in multiple sclerosis by ultra-high field MRI

Constantina Andrada Treaba1,2, Elena Herranz1,2, Russell Ouellette IV1, Tobias Granberg1,2,3,4, Celine Louapre1,2, Valeria Barletta1,2, Ambica Mehndiratta1, Jacob A Sloane2,5, Revere Kinkel6, and Caterina Mainero1,2

1Department of Radiology, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, 4Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, 5Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 6Department of Neurosciences, University of California, San Diego, CA, United States

Cortical lesions (CL) and cortical atrophy are frequent in multiple sclerosis (MS) and main determinants of disease progression. The relationship between them is still unknown, mostly due to the low sensitivity of clinical magnetic resonance imaging (MRI) to CL. Disconnection from white matter (WM) lesions has also been proposed as a pathogenic mechanism for cortical MS atrophy. Using 7 Tesla MRI that has shown increased sensitivity to CL than clinical MRI, we showed, in a large MS cohort that WM lesions are the main determinant of cortical thinning. Nevertheless, CL resulted as the main contributors of physical and cognitive disability.

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