Abstract #0075

Combined Gadoxetic Acid and Gadobenate Dimeglumine Enhanced Liver MRI for Liver Metastasis Detection: A Parameter Optimization Study

Gesine Knobloch¹, Timothy Colgan¹, Xiaoke Wang^1,2, Tilman Schubert¹, Diego Hernando³, and Scott Reeder^1,2,3,4,5

¹Department of Radiology, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ²Department of Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ³Department of Medical Physics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁴Department of Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁵Department of Emergency Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States

The detection of small perivascular metastatic lesions can be challenging with gadoxetic acid-enhanced liver MRI because both, blood vessels and metastases appear hypointense during the hepatobiliary phase. We sought to demonstrate the feasibility of combined gadoxetic acid (GA)/gadobenate dimeglumine (GD) liver MRI for improved lesion detection and optimize the imaging protocol regarding GA-dosing, imaging time after GD-injection and flip angle. Preliminary results show a homogenously enhanced liver and vasculature (“plain-white-liver”) 1-3min after GD-bolus detection with optimal contrast using flip angles of 25-35°. The combined GA/GD protocol has potential to improve the diagnostic performance of hepatobiliary phase liver MRI.

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