Abstract #5646

Altered intrinsic neuronal activity correlates with GABA levels in the auditory region of patients with presbycusis

Fei Gao¹, Guangbin Wang¹, Bin Zhao¹, Fuxin Ren¹, and Weibo Chen²

¹Shandong Medical Imaging Research Institute, Shandong University, JINAN, People's Republic of China, ²Philips Healthcare, Shanghai, People's Republic of China

In this study, we used J-difference edited MRS and resting-state fMRI to investigate correlation between intrinsic neuronal activity and GABA levels in the auditory cortex of patients with presbycusis. Our results indicated that abnormalities in GABAergic neurotransmission may underlie resting-state functional deficits in presbycusis.

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