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Abstract #5641

Cerebral Metabolite Changes and Cognitive Clinical Correlates in Perinatally HIV-infected Young Adults

Manoj K Sarma1, Margaret A Keller2, Tamara Welikson3, Sathya Arumugam 1, David E Michalik4, Irwin Walot5, Karin Nielsen-Saines6, Jaime Deville6, Andrea Kovacs7, Eva Operskalski7, Joseph Ventura8, and M. Albert Thomas1

1Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, United States, 2Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States, 3Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA, United States, 4Infectious disease-Pediatrics, Miller Children's Hospital, Long Beach, CA, United States, 5Radiology, Harbor-UCLA Medical Center, Torrance, CA, United States, 6Pediatrics, UCLA School of Medicine, Los Angeles, CA, United States, 7Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, United States, 8Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States

A recently implemented 5D echo-planar J-resolved spectroscopic sequence using 8x acceleration and compressed sensing reconstruction was evaluated in 7 perinatally infected and 8 healthy youths. Selected metabolite ratios with respect to Cr were detected bilaterally in the basal ganglia, anterior insular cortex, posterior insular cortex, frontal white and occipital/frontal gray regions of the two groups. Statistically significant differences were found between metabolite ratios (/Cr) of HIV-infected youing adults and healthy control subjects in the occipital gray N-acetylaspartate, right basal ganglia glutamine/glutamate, left anterior insular cortex choline, and left posterior insular cortex. Also, our pilot findings suggest a possible difference in energy metabolism between perinatally HIV-infected young adults and controls without HIV. The metabolite ratios correlated with neuropsychological test scores showing cognitive impairment as result of HIV-infection and/or long term ART.

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