Abstract #5638

Reproducibility for MRS-Based Relaxometry and Identification of Influential Parameters

Bernhard Neumayer^1,2, Thomas Widek^1,2, Chris Boesch³, and Eva Scheurer⁴

¹Ludwig Boltzmann Institute for Clinical Forensic Imaging, Graz, Austria, ²BioTechMed-Graz, Graz, Austria, ³Department of Clinical Research (AMSM), University of Bern, Bern, Switzerland, ⁴Department of Forensic Medicine, University of Basel, Basel, Switzerland

The different relaxation times of the water and the fat compartment in human lumbar vertebrae make it necessary to determine these values for a correct calculation of the fat fraction, which is used as a biomarker for various applications. This study investigates the reproducibility of relaxometry in human lumbar vertebrae to serve as a basis for future studies. Furthermore, factors like age, sex, and physique are investigated for their influence on the derived T₁ and T₂ values to investigate whether relaxation times of the fat and water compartments can serve as biomarkers in addition to the fat fraction.

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