The aim of the present study was to test a novel method for improving the subcortical tissue segmentation results, of the anatomical brain images acquired using a 31P/1H dual-tuned coil. When a dual-tuned 31P/1H coil is utilized to perform phosphorus-31 magnetic resonance spectroscopy studies of subcortical brain regions, the resulting anatomical images suffer from both low signal-to-noise ratio, and from reduced image contrast. By registering this volume image on a second anatomical image acquired using a single-tuned, 12 channel 1H head coil, we found that the subcortical tissue segmentation accuracy was significantly improved.
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