Abstract #5606

Metabolomic Analysis of Dendritic Cell Vaccination

Ram Bahadur Khattri¹, Farhad Dastmalchi², James R. Rocca³, Maryam Rahman², and Matthew Merritt⁴

¹Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States, ²Department of Neurosurgery, University of Florida, Gainesville, FL, United States, ³Mcknight Brain Institute, University of Florida, Gainesville, FL, United States, ⁴Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States

We use ¹H NMR metabolomics to measure the impact of immunotherapy intended to target glioblastoma multiforme in a murine model. Cellular immunotherapy is a promising new platform for cancer treatment. Analysis of the urine of C57Bl6 mice revealed a set of metabolites associated with changes in glycolysis after immunotherapy treatment.

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