One-dimensional transverse relaxometry has proven to be an effective method for characterizing macromolecular compartments in cartilage. Two-dimensional studies extend the capabilities of these types of experiments, providing characterization of tissue compartments in terms of correlated relaxation times and providing a means of probing intercompartmental exchange. We provide results of T2-T2 and T1-T2 relaxometry experiments on human articular cartilage, indicating that exchange between tissue compartments may be augmented in degraded tissue.
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