The role of lactate in neuronal activation is central in the hypothesis of the astrocyte-to-neurons lactate shuttle. In this work, we implement highly sensitive 1H-MRS on brain microdialysate in order to monitor online the lactate fluctuations during neuronal activation in the S1BF area. The custom-made microcoil used in this study was shown to be sensitive enough for measuring a 40% increase in lactate concentration during brain stimulation.
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