Proton MR spectroscopic imaging (MRSI) is complicated by the presence of subcutaneous lipids, which, if not suppressed before Fourier reconstruction, cause ringing in metabolite maps due to limited k-space sampling. In this study inversion recovery (IR) based lipid suppressed acquisition was compared to non-lipid suppressed acquisition combined with two methods for reducing lipid ringing in whole brain MRS imaging. Results indicate non-lipid suppressed acquisition using the ℓ2-regularization or Papoulis-Gerchberg algorithm for reconstruction is possible without significant ringing artifacts, however, can have a detrimental effect on spectral linewidth and baseline, resulting in smaller spatial coverage than IR based lipid-suppressed acquisition.
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