The presence lipids of several orders of magnitude higher concentrations than metabolites in the extracranial tissues present significant challenges for the reliable acquisition and quantification of 1H MRSI, especially in the outer perimeter areas of the brain. We developed a novel spatial lipid reconstruction technique to remove nuisance lipid signals in 1H MRS. We applied lipid reconstruction to MRSI data and performed BASE-SLIM localization on the lipid-subtracted signal. Using this method, high quality compartment spectra of GM and WM could be obtained.
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