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Abstract #5486

Repeatability of myocardial creatine and triglyceride concentration measurements with 1H-MRS

Adrianus J. Bakermans1, Paul de Heer1,2, Gustav J. Strijkers3, S. Matthijs Boekholdt4, Aart J. Nederveen1, and Jeroen A.L. Jeneson1,5

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 4Department of Cardiology, Academic Medical Center, Amsterdam, Netherlands, 5Neuroimaging Center, University Medical Center Groningen, Groningen, Netherlands

Changes in myocardial total creatine (tCr) and triglyceride (TG) content have been linked to the pathogenesis of cardiomyopathy. An assessment of repeatability for absolute quantification of myocardial [tCr] and [TG] is required for 1H-MRS to be employed for longitudinal monitoring of therapeutic efficacy. This work reports intra- and inter-exam repeatability of [tCr] and [TG] measurements with 1H-MRS at 3 Tesla. Our results indicate that the repeatability of the 1H-MRS assay will be sufficient to detect a >50% depletion of the tCr pool, and >50% changes in myocardial TG levels with 95% confidence in a single subject.

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