Recent reports indicate that cerebrovascular reactivity (CR) may be impaired in multiple sclerosis (MS). Here we report initial studies to use simultaneous measurements of electroencephalography (EEG) and BOLD during performance of a motor task. Using EEG-derived predictors of BOLD response, we show that, while EEG robustly predicts the amplitude of the BOLD signal in healthy control subjects, the estimation is very poor in MS patients. This could be direct evidence of cerebrovascular decoupling of the BOLD signal in MS.
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