Abstract #5393

How does chronic neuroinflammation affect resting state functional connectivity?

Esteban Adrian Oyarzabal^1,2,3, SungHo Lee^1,4,5, Manasmita Das^1,2, Sheng Song^6,7, and Yen-Yu Ian Shih^1,2

¹Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Neurobiology Laboratory, National Institute of Environmental Health Sciences, RTP, NC, United States, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, ⁶Neurobiology Laboratory, National Institute of Environmental Health Sciences, ⁷National Institute of Environmental Health Sciences, RTP, NC, United States

Chronic neuroinflammation, present in most neuropathologies, has long-term consequences on neurocircuit connectivity synchrony and strength. By implementing multi-modal techniques to quantify neuroinflammation, we found a strong association linking the intensity of neuroinflammation with depressed functional connectivity. We partly attribute these changes to neurodegeneration and the loss of central NE.

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