Abstract #5391

Diffusion kurtosis imaging with tract-based spatial statistics reveals white matter alterations in children with obstructive sleep apnea syndrome

Wenfeng Li¹, Hongwei Wen², Yun Peng¹, Hongbin Li¹, Yang Wen¹, Hua Cheng¹, Yang Fan³, Huiguang He², and Yue Liu¹

¹Beijing Children's Hospital,Capital Medical University, Beijing, People's Republic of China, ²Chinese Academy of Sciences, Beijing, People's Republic of China, ³GE Healthcare, Beijing, People's Republic of China

It is reported that OSAS may cause cognitive function disorder of children due to chronic hypoxia for a long time［1］. However, it is not clear whether there are any structural changes of cerebral regions, e.g. white matter (WM). Diffusion kurtosis imaging is now widely used in the detection of cortical structural changes across kinds of diseases. In the present study, DKI is used to investigate microstructural changes of WM in OSAS children compared with normal healthy controls.

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