Abstract #5388

Stimulus-evoked fMRI activations are a subset of resting-state fMRI networks in the rat olfactory bulb

Garth J Thompson^1,2, Basavaraju G Sanganahalli^1,2,3, Keeley Baker^4,5, Justus V Verhagen^4,5, Gordon M Shepherd⁵, and Fahmeed Hyder^1,2,3,6

¹Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, United States, ³Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, Yale University, New Haven, CT, United States, ⁴The John B. Pierce Laboratory, New Haven, CT, United States, ⁵Neurobiology, Yale University, New Haven, CT, United States, ⁶Biomedical Engineering, Yale University, New Haven, CT, United States

Are coordinated activations of the brain during sensory stimulation linked to the synchronized activations or “functional connectivity” observed with resting state fMRI? We recorded odor-stimulation fMRI and resting state fMRI in the rat olfactory bulb’s glomerular sheet. Glomerular activations due to three odors were compared to spontaneous fluctuations organized as twenty-two independent component networks. Networks correlated with activation in an odor-specific manner. We reconstructed approximations of activation which retained odor specificity for two of three odors, despite being constructed from resting state data. Our results suggest a function for synchronized resting oscillations in reinforcing stimulation-specific responses.

This abstract and the presentation materials are available to members only; a login is required.

Join Here