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Abstract #5376

The Early Global Function Connectivity Stability in Infants during the Neonatal Period

Yue Cai1,2, Yuan Shi3, Yang Fan4, Wei Gao5,6, and Jiahong Gao2

1Department of Biomedical Engineering, Peking University, beijing, People's Republic of China, 2Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, 3Daping Hospital, Third Military Medical University, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China, 4MR Research China, GE Healthcare, Beijing, People's Republic of China, 5Biomedical Imaging Research Institute (BIRI), Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, los angeles, CA, United States, 6Department of Radiology and Biomedical Research Imaging Center, University of North Carolina Chapel Hill, United States

This study proposes an improved method named global functional connectivity stability (GFCS) to quantify the brain dynamic functional connectivity at a voxel-wise level. The GFCS was applied to investigate the overall functional connectivity stability and its correlation with time in infants during the period from late preterm to the term equivalent age (TEA). It is shown that infants presented high functional stability predominantly in the sensorimotor areas, temporal lobe, posterior cingulate cortex (PCC) and medial prefrontal cortex. With time, the frontal areas appeared more variable while the sensorimotor cortex appeared more stable in infants during the neonatal period.

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