The validity of BOLD fMRI in pre-surgical planning may be severely compromised due to disruption of the normal coupling between neural activity and the consequent microvascular blood flow response (neurovascular uncoupling, or NVU). The effects of brain tumor-induced NVU on resting state BOLD fMRI (rsfMRI) have been previously described through seed-based correlation analysis (SCA). In this study, we evaluated regional homogeneity of resting state fMRI data using Kendall's coefficient of concordance (KCC-ReHo) & Coherence (Cohe-ReHo) metrics and compared these results with those of “gold standard”motor task-based (tbfMRI) activation to determine their effectiveness in detecting NVU in the sensorimotor network.
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