Two multi-breath imaging techniques for quantifying specific ventilation based on oxygen enhanced 1H and hyperpolarized 3He gas MRI were cross-validated with spatially matched data from the same subjects. With a custom RF torso 1H array configured with 3He T-R coil in situ we were able to separately acquire 1H and hyperpolarized 3He MRI during a single scanning session without repositioning the subject. The preliminary study demonstrated qualitative as well as quantitative similarities between the two techniques.
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