Abstract #5281

The GABA Level in DMN Modulate the Brain Network Centrality

Tun-Wei Hsu^1,2, Jy-Kang Adrian Liou^1,2, Chien-Yuan Eddy Lin^3,4, Ralph Noeske⁵, and Jiing-Feng Liring^1,6

¹Department of Radiology, Taipei Veterans General Hospistal, Taipei, Taiwan, ²Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ³GE Healthcare, Taipei, Taiwan, ⁴GE Healthcare MR Research China, Beijing, People's Republic of China, ⁵GE Healthcare, Berlin, Germany, ⁶Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

In this study, we combined resting-state functional magnetic resonance imaging (rsfMRI) and advanced magnetic resonance spectroscopy technique to demonstrate a positive relationship between levels of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) within posterior cingulate cortex/precuneus (PCC/PCu) and high network centrality of primary network. High network centrality propagates and contributes to efficient information flow in brain network. The PCC/PCu is a key component of default mode network (DMN) and high regional GABA levels expressing in the PCC/PCu area deactivate DMN activities related to internal thoughts for reallocating attention resources from internal processes to goal directed external stimuli with high network centrality.

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