Abstract #5279

Increased resting-state functional connectivity within subgenual anterior cingulate cortex network reveals the neural substrate of emotion regulation following mindfulness-based stress reduction (MBSR) training

Yao-Chia Shih^1,2, Chang-Le Chen^2,3, Shih-Chin Fang⁴, Tzung-Kuen Wen⁵, Da-Lun Tang⁶, Si-Chen Lee⁷, and Wen-Yih Isaac Tseng^2,3,8

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ³Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Neurology, Cardinal Tien Hospital Yonghe Branch, New Taipei City, Taiwan, ⁵Department of Buddhist Studies, Dharma Drum Institute of Liberal Arts, New Taipei City, Taiwan, ⁶Department of Mass Communication, Tamkang University, Taipei, Taiwan, ⁷Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ⁸Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Mindfulness-based stress reduction (MBSR) has been known to improve emotion regulation and cure mood disorders. The present longitudinal study aimed to clarify the effects of MBSR training and practice on the neural substrates of emotion regulation. Resting-state functional MRI (rsfMRI) exams were performed at three time points to investigate changes of functional connectivity (FC) within the subgenual anterior cingulate cortex (sgACC) network. MBSR training and practice strengthened the FC of sgACC with the inferior frontal gyrus and with the insula, and reduced the level of anxiety and depression. The findings reveal the neural substrates of emotion regulation process following MBSR.

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