Streamlined Quantitative-BOLD provides a method for quantifying brain oxygen metabolism, in particular, deoxygenated blood volume and oxygen extraction fraction, based on linear fitting of values obtained from an asymmetric spin-echo sequence. It is possible that a curve-fitting approach may yield more robust values for these parameters. This study investigated the feasibility of estimating brain metabolic and vascular parameters through a Bayesian framework, through simulations, and analysis of patient data. It was found that under the current model, simultaneous estimation of oxygen extraction fraction and blood volume was not reliable, suggesting a limit to the model or acquisition protocol.
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