Current Multi-Echo fMRI approach can only acquire up to three echoes due to the fast T2* decay. We hypothesized that more echo will improve the capability of increasing the BOLD CNR and denoise accuracy, and we managed to acquire up to six echoes using our within TR keyhole based approach: SCITH. Our preliminary data showed increased BOLD CNR and resting-state functional connectivity(FC), less temporal FC fluctuation and more consistent inter-subject FC in the same population.
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