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Abstract #5191

Accurate and reliable fat-water MRI breast density measurements

Jie Ding1, Patricia A Thompson2,3, Yi Gao4,5, Marilyn T Marron6, Betsy C Wertheim6, Maria I Altbach6,7, Jean-Philippe Galons6,7, Denise J Roe6,8, Fang Wang9, Gertraud Maskarinec10, Cynthia A Thomson6, Alison Stopeck3,11, and Chuan Huang1,5,12,13

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Pathology, Stony Brook Medicine, Stony Brook, NY, United States, 3Cancer Center, Stony Brook Medicine, Stony Brook, NY, United States, 4Biomedical Informatics, Stony Brook Medicine, Stony Brook, NY, United States, 5Computer Science, Stony Brook University, Stony Brook, NY, United States, 6Cancer Center, University of Arizona, Tucson, AZ, United States, 7Medical Imaging, University of Arizona, Tucson, AZ, United States, 8Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States, 9Stony Brook Medicine, Stony Brook, NY, United States, 10Cancer Center, University of Hawaii at Manoa, Honolulu, HI, United States, 11Hematology and Oncology, Stony Brook Medicine, Stony Brook, NY, United States, 12Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 13Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States

Breast density (BD) is a risk factor for breast cancer, which makes the accurate measurement of BD a priority. Mammography is most widely used for BD determination (MG-BD) but ionizing radiation prohibits its use. BD derived from fat-water decomposition MRI (FWMRI-BD) has been proposed. Here we developed an optimized FWMRI-BD measurement (FraG+W) and compared it to MG-BD and a previous FWMRI-BD measurement (Fra80/90). Both FWMRI-BD measures were strongly correlated with MG-BD and exhibited superior test-retest reliability. The proposed automated FraG+W, which quantifies the entire fibroglandular and water content of the breast, is more accurate and reliable than the previous Fra80/90.

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