The assessment of vertebral bone marrow fat unsaturation is attracting growing interest for applications in bone metabolism and osteoporosis. Especially in younger subjects, the presence of a strong and broad water peak confounds the extraction of surrounding peaks (olefinic and glycerol peaks), which are used for the determination of fat unsaturation. Inversion-recovery spectroscopy allows the extraction of these peaks by differentiating the signals based on different T1 relaxation times between water and fat. The feasibility of using inversion-recovery spectroscopy was evaluated in a phantom experiment in comparison with gas chromatography and in vivo in four young and healthy volunteers.
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