This study presents a new diffusion tool based on a novel single-shot 2D MRI method called xSPEN. xSPEN is characterized with unusual resilience to field heterogeneities, but extending it to DTI requires to overcome the strong intrinsic diffusion weighting of this technique. To achieve this we formulated xSPEN’s diffusion weighting using a novel, spatially localized b- matrix analysis, and devised a novel diffusion-weighting scheme that overcomes xSPEN’s original limitations. These methods were numerically validated and applied to new DTI xSPEN sequences with which we mapped diffusion in often unreachable human head regions, including optic nerve and olfactory bulb regions.
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