T1ρ and Dynamic BOLD MR imaging to evaluate the change of skeletal muscles of lower extremity in diabetes patients

This study aimed to measure the BOLD response in the calf muscle in T2DM patients during post-occlusive reactive hyperemia and to study whether T1ρ MR Imaging of calf muscle could differentiate T2DM patients from normal subjects. Twenty-two T2DM patients and twenty age-matched healthy volunteers were performed MR scanning. T1ρ relaxation time and maximal ΔT2* change (ΔT2*max) and time to peak (TTP) were measured. Our results showed that the lower degree of the increase (ΔT2*max and TTP) in calf muscles of DM patients. In addition, T1ρ relaxation time in TA muscle was significant higher in DM patient than in healthy subjects.