This study aimed to assess the diagnostic accuracy of DKI technique in breast cancer patients, and to evaluate the potential associations between DKI-derived parameters and cellular proliferation of breast cancer. Mean kurtosis (MK) derived from DKI exhibited the maximal AUCs (0.972) and corresponding optimal sensitivity (90.2%) and specificity (95.2%) for distinguishing malignancy from benign lesions. Furthermore, positive correlation between MK and pathological prognostic factors (Ki-67 expression and histological grade) were found. Preliminary findings highlighted the potential utility of DKI as a sensitive MR sequence for imaging studies and diagnostic improvement of breast masses.
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