Asthma is a worldwide chronic respiratory disease. The common treatment by inhaled therapy needs quantitative imaging approaches to understand the impact of carrier gas on aerosol deposition. 3D UTE-MRI combined with aerosolized Gd-DOTA was applied onto spontaneous breathing and mechanically ventilated asthmatic animals. Here, administration and imaging protocols were developed to ventilate and nebulize control and asthmatic rats in order to compare the resulting aerosol distribution with two carrier gas mixtures: air and helium-oxygen.
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