We used simultaneous MR/FDG PET to measure the myocardial extracellular volume (ECV) and glucose metabolism (estimated by standard uptake value, SUV) in a canine model of chemotherapy (ChT); comparison was made to ECV in relationship to a myocardial infarct (MI) models. MRI ECV in the ChT group was elevated by 16% and 23% compared to the MI group in the remote and adjacent myocardial segments, respectively. PET SUV in the ChT group was reduced by 49% and 41% compared to the MI group in the remote and adjacent myocardial segments, respectively. Difference was also observed in the MRI partition coefficient but not in the native T1.
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