Pulmonary fibrosis has high morbidity and mortality, but remains poorly understood. Many experimental and clinical studies have implied or demonstrated the role for transforming growth factor (TGF)-α in the pathogenesis of pulmonary fibrosis. We demonstrate the utilization of retrospective self-gating UTE MRI with ellipsoidal k-space coverage to measure the burden of pulmonary fibrosis in a TGF-α transgenic mouse model, with the dynamic progression of fibrotic burden well quantified longitudinally by both high-density lung volume percentage and tidal volume.
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