Abstract #4835

Quantitative BOLD MRI and T1 Mapping in Acute Kidney Injury Patients: A preliminary study

Yingjie Mei^1,2, Xiang Xiao³, Zihan Lei⁴, Jie Feng³, Yuankui Wu³, Ruiying Chen³, Qiangqiang Gang³, Min Liang⁴, Yikai Xu³, and Yanqiu Feng¹

¹School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guangzhou, People's Republic of China, ²Philips Healthcare, Guangzhou, People's Republic of China, ³Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, People's Republic of China, ⁴Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China

Hypoperfusion and hypoxia are thought to be important factors in the pathogenesis of AKI and in the progression from AKI to chronic kidney disease. Previous studies have demonstrated the correlation between MR relaxation time (T1 and T2*) and tissue oxygenation. The result of this preliminary study suggests BOLD and T1 mapping are potential to diagnose AKI at early stage and predict the progression of AKI non-invasively.

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