Abstract #4801

Perfusion MRI of the Placenta: Preliminary Results using ASL FAIR and Ferumoxytol DCE MRI in the Rhesus Macaque

Kai D. Ludwig¹, Sean B. Fain^1,2,3, Sydney Nguyen⁴, Thaddeus G. Golos^4,5, Scott B. Reeder^1,2,3,6,7, Ian M. Bird⁵, Oliver E. Wieben^1,2, Dinesh M. Shah⁵, and Kevin M. Johnson¹

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁴Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁵Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁷Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Non-contrast enhanced methods are needed to quantify placental perfusion to detect and monitor pathophysiological changes during pregnancy. We evaluate the potential of an endogenous perfusion labeling perfusion technique, Arterial Spin Labeled Flow-sensitive Alternating Inversion Recovery (ASL FAIR), and compare with ferumoxytol dynamic contrast enhanced (DCE) MRI. Three pregnant rhesus macaque were imaged with both FAIR and ferumoxytol DCE. Localized regions of ASL perfusion were observed that coincided with regions of early contrast enhancement seen in DCE. Ferumoxytol DCE measured perfusion with extended transit times across the placenta beyond those typically used for ASL labeling.

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