Whilst multi-scanner studies provide the most robust evidence for quantitative imaging trials, they tend to be limited by poor reproducibility of scans performed on different scanners. In this study, 14 patients underwent paired multiparametric prostate MRI within 3 months of each other. We found that normalisation of T2 signal to the bladder improved the reproducibility of both peripheral zone and transition zone metrics considerably when compared with the current convention of using obturator internus. Whilst ADC also met sufficient levels of reproducibility, semiquantiative and quantitative DCE analysis and histographic features failed to do so.
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