Abstract #4727

Arterial transit time measured by multi-delay ASL perfusion for evaluating major cerebral artery stenosis/occlusive disease: correlation with 15O-H2O 　and 15O2 gas PET-CBF and OEF

Kayo Takeuchi¹, Makoto Isozaki², Masayuki Kanamoto¹, Yoshifumi Higashino², Hidehiko Okazawa³, Kenichiro Kikuta², R Marc Lebel⁴, and Hirohiko Kimura¹

¹Department of Radiology, University of Fukui, Fukui, Japan, ²Department of Neurosurgery, University of Fukui, Fukui, Japan, ³Biomedical Imaging Center, University of Fukui, Fukui, Japan, ⁴GE Healthcare, Calgary, Canada

Positron emission computed tomography (PET) is used for evaluating cerebral hemodynamic ischemic stages in patients with major cerebrovascular stenosis/occlusion for treatment indication. Using a rapid, low-resolution pre-scan method, arterial transit time (ATT) and corrected cerebral blood flow (CBF) could be obtained, even in the immediate clinical setting. This study aimed to clarify whether ATT is hemodynamically related to misery perfusion stratified with ¹⁵O-H₂O/¹⁵O₂-gas PET data. There was a significant correlation between ASL and PET CBF before and after ATT correction (r²=0.27, 0.55). ATT also significantly correlated with PET-OEF (r²=0.11) and is a useful parameter to classify cerebral ischemia.

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Arterial transit time measured by multi-delay ASL perfusion for evaluating major cerebral artery stenosis/occlusive disease: correlation with 15O-H2O and 15O2 gas PET-CBF and OEF

Arterial transit time measured by multi-delay ASL perfusion for evaluating major cerebral artery stenosis/occlusive disease: correlation with 15O-H2O 　and 15O2 gas PET-CBF and OEF