Abstract #4722

Triple Magnetic Resonance Angiography (triple-MRA) for planning of Gamma Knife Radiosurgery of brain arteriovenous malformations

Alvaro Rojas Villabona^1,2, Magdalena Sokolska^3,4, Enrico De Vita⁴, Mary Murphy², Thomas Solbach⁵, Joan Grieve², Prem Rangi⁵, Yuriko Suzuki⁶, Matthias JP Van Osch⁶, David Atkinson⁷, Emma Biondetti³, Karin Shmueli³, Xavier Golay⁴, Ian Paddick¹, Neil Kitchen², and Hans Rolf Jäger^4,5

¹The Gamma Knife Centre at Queen Square, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ²Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁴Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, ⁵The Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁶C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Centre for Medical Imaging, University College London, London, United Kingdom

This study investigates whether a combination of three MRA techniques, referred to as triple-MRA, could be used as an alternative to DSA for visualisation and delineation of brain AVMs for GKR targeting. The AVMs of 13 patients undergoing GKR were delineated using triple-MRA and the resultant target volumes were compared to the radiosurgical targets generated by the neurosurgical team using DSA and volumetric contrast T1/T2 imaging. Target volumes obtained using triple-MRA are comparable to target volumes obtained with DSA and used for delivery of GKR. In conclusion, triple-MRA is a robust method for non-invasive identification and delineation of brain AVMs.

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