Extraction of Dentatorubrothalamic Fiber Tracts in Human Brain Using Probabilistic Fiber Tracking and Unsupervised Clustering Algorithm

We proposed a novel robust method to extract the dentatorubrothalamic tract (DRTT) in the human brain from DTI images. First, the method was tested on healthy control subjects, then on 30 medulloblastoma patients who had undergone resection of their posterior fossa tumors. Patterns of bilateral, left only, right only and even no DRTT were observed. Validation with multiple manual ROIs along the known pathway confirmed the extracted DRTTs. This suggests that the proposed method may provide an object way to access the DRTTs in medulloblastoma patients post-surgery.